With this question (based on a suggestion by Shaun Inman), I'm hoping the discussion touches on a few different things that happen to be going on.

I'll leave it at that for now, and let you all weigh in.

Q: When marking up a book title or publication, which of the following is the best choice?

1. <p>My upcoming book, <em>SimpleQuiz: Get Down With Markup</em>, will be a bestseller.</p>
2. <p>My upcoming book, <i>SimpleQuiz: Get Down With Markup</i>, will be a bestseller.</p>
3. <p>My upcoming book, <cite>SimpleQuiz: Get Down With Markup</cite>, will be a bestseller.</p>